Oligopeptide transmembrane transport

Across TCGA cell cohorts, RNA activity of the Oligopeptide transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC1, KCTD1, and DLC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligopeptide transmembrane transport activity versus ABCC1 in BLOOD_Lymphoma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ABCC1 →	+1.155	+0.476	.005	.004	3	4
KIDNEY	KCTD1 →	+1.716	+1.384	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	DLC1 →	-2.308	-1.429	.001	.002	3	3
BLOOD_Lymphoma	RPL32 →	-0.725	-0.476	.001	.004	3	3
KIDNEY	SLC43A3 →	-5.050	-1.708	.006	.009	3	3
LUNG_NSCLC_LUAD	CD274 →	-2.164	-1.585	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035672 vs ABCC1 — BLOOD_Lymphoma

Explore this scatter interactively →