Clathrin-coated vesicle cargo loading

Across TCGA patient cohorts, RNA activity of the Clathrin-coated vesicle cargo loading pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP3M2, SLC20A2, and VDAC3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin-coated vesicle cargo loading activity versus AP3M2 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AP3M2 →	+0.314	+0.064	<.001	<.001	3	8
LUAD	SLC20A2 →	+0.398	+0.050	<.001	<.001	3	5
UCEC	VDAC3 →	+0.893	+0.071	<.001	<.001	3	5
PDAC	POLB →	+0.547	+0.052	<.001	<.001	3	5
LUAD	POMK →	+0.394	+0.046	.005	.003	2	6
COAD	FNTA →	+0.188	+0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035652 vs AP3M2 — LSCC

Explore this scatter interactively →