Clathrin-coated vesicle cargo loading

Across TCGA patient cohorts, RNA activity of the Clathrin-coated vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBL1XR1-AS1, LINC00706, and DNAJC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin-coated vesicle cargo loading activity versus TBL1XR1-AS1 in HNSC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TBL1XR1-AS1 →	-0.567	-0.097	.006	.003	2	5
GBM	LINC00706 →	+0.320	+0.082	.005	.007	3	4
LUAD	DNAJC2 →	-0.309	-0.144	.002	.003	3	3
LSCC	PPM1D →	-0.371	-0.170	.003	.001	3	3
LUAD	CDC42EP4 →	-0.428	-0.136	.003	.002	3	3
LUAD	C16orf72 →	-0.256	-0.109	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035652 vs TBL1XR1-AS1 — HNSC

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