Clathrin-coated vesicle cargo loading

Across TCGA patient cohorts, RNA activity of the Clathrin-coated vesicle cargo loading pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP3D1, AP3D1_S829, and METTL14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin-coated vesicle cargo loading activity versus AP3D1 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AP3D1 →	+0.215	+0.199	.001	<.001	3	6
LUAD	AP3D1_S829 →	+0.982	+0.263	<.001	<.001	3	4
COAD	METTL14 →	-0.598	-0.205	<.001	<.001	3	3
OV	RIN1_S258 →	+0.733	+0.226	<.001	<.001	3	3
OV	NR2C1_S215 →	+0.456	+0.106	.001	.001	3	3
GBM	SIRPA →	+0.591	+0.133	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035652 vs AP3D1 — BRCA

Explore this scatter interactively →