Clathrin-coated vesicle cargo loading

Across TCGA cell cohorts, RNA activity of the Clathrin-coated vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL13A, ARSK, and CMAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL13A grouped by Clathrin-coated vesicle cargo loading-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPL13A →	+0.781	+0.703	<.001	.007	3	4
BLOOD_Leukemia	ARSK →	-0.654	-0.855	.003	.004	3	4
LUNG_NSCLC_LUAD	CMAS →	-0.490	-0.617	.006	.003	3	4
SOFT_TISSUE	CDC25B →	-1.695	-1.760	.009	<.001	3	4
OVARY	STRIP2 →	-1.143	-0.969	.007	.004	2	5
OVARY	SPOCD1 →	-1.679	-0.897	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL13A by Clathrin-coated vesicle cargo loading activity — BLOOD_Leukemia

Explore this box plot interactively →