Locomotory exploration behavior

Across TCGA patient cohorts, RNA activity of the Locomotory exploration behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBN2_S13, DPP4, and FNBP4_S18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Locomotory exploration behavior activity versus UBN2_S13 in LUAD (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UBN2_S13 →	-0.560	-0.084	<.001	<.001	3	7
LUAD	DPP4 →	+0.827	+0.099	<.001	<.001	3	7
LUAD	FNBP4_S18 →	-0.557	-0.088	<.001	<.001	3	6
BRCA	EEF1B2 →	-0.269	-0.030	.002	.006	2	7
LUAD	RPP25_S162 →	-1.212	-0.115	<.001	<.001	3	5
LUAD	RPS18 →	-0.332	-0.067	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035641 vs UBN2_S13 — LUAD

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