Locomotory exploration behavior

Across TCGA cell cohorts, RNA activity of the Locomotory exploration behavior pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF619, FBXL12, and ZNF529, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Locomotory exploration behavior activity versus ZNF619 in SOFT_TISSUE (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF619 →	-0.901	-1.640	.004	<.001	3	3
BREAST	FBXL12 →	+0.555	+0.641	.008	.003	3	3
BREAST	ZNF529 →	+0.903	+0.675	.001	.001	3	3
LUNG_SCLC	FBXL22 →	-0.747	-0.696	<.001	.003	3	3
LARGE_INTESTINE	COX15 →	-0.672	-1.258	.001	<.001	3	3
LIVER	SRA1 →	-0.782	-0.251	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035641 vs ZNF619 — SOFT_TISSUE

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