Exploration behavior

Across TCGA patient cohorts, RNA activity of the Exploration behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS18, ABAT, and AHCTF1_S1541, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exploration behavior activity versus RPS18 in LUAD (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS18 →	-0.319	-0.056	.001	.002	3	6
BRCA	ABAT →	+0.924	+0.033	<.001	<.001	3	6
BRCA	AHCTF1_S1541 →	-0.858	-0.043	<.001	.003	3	6
LUAD	UBN2_S13 →	-0.564	-0.067	<.001	<.001	3	5
GBM	DNAJB11 →	-0.364	-0.095	<.001	<.001	3	5
CCRCC	SERBP1 →	-0.149	-0.057	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035640 vs RPS18 — LUAD

Explore this scatter interactively →