Exploration behavior

Across TCGA cell cohorts, RNA activity of the Exploration behavior pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT8, EIF4A3, and UBE2O, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACOT8 grouped by Exploration behavior-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACOT8 →	+0.425	+0.160	.003	<.001	3	4
PANCREAS	EIF4A3 →	-0.668	-0.213	<.001	.001	3	4
PANCREAS	UBE2O →	-0.796	-0.225	<.001	<.001	3	4
LUNG_NSCLC_LUAD	BSPRY →	+1.591	+0.161	.001	<.001	3	3
LUNG_NSCLC_LUAD	C11orf52 →	+1.115	+0.181	.001	<.001	3	3
LUNG_NSCLC_LUAD	TMEM125 →	+2.012	+0.189	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACOT8 by Exploration behavior activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →