Exploration behavior

Across TCGA cell cohorts, RNA activity of the Exploration behavior pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, CD59, and PPFIA3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exploration behavior activity versus FLNA in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FLNA →	+1.996	+0.343	.001	.001	3	9
BONE	CD59 →	+2.229	+0.501	.002	.005	3	8
BONE	PPFIA3 →	-2.364	-0.410	.001	.002	3	7
BONE	PPP1R18 →	+1.554	+0.440	<.001	<.001	3	7
BONE	TNFRSF12A →	+3.932	+0.375	<.001	.001	3	7
LIVER	S100A3 →	+2.912	+0.272	.002	.008	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035640 vs FLNA — BREAST

Explore this scatter interactively →