Exploration behavior

Across TCGA cell cohorts, RNA activity of the Exploration behavior pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA3, APOE, and CRBN, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exploration behavior activity versus ITGA3 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ITGA3 →	+2.697	+0.344	.003	<.001	3	12
STOMACH	APOE →	+1.963	+0.256	<.001	.003	3	11
BONE	CRBN →	+1.235	+0.379	<.001	<.001	3	10
BREAST	TAPBP →	+1.768	+0.271	<.001	.002	3	9
BONE	AP2M1 →	+1.095	+0.325	<.001	<.001	3	8
BONE	CD59 →	+2.124	+0.378	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035640 vs ITGA3 — BLOOD_Lymphoma

Explore this scatter interactively →