Entry of bacterium into host cell

pathway activity — cross-omics
GO:0035635Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Entry of bacterium into host cell pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, SERPINH1, and SERPINF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECACTN1 →+0.474+0.073<.001.00237
GBMSERPINH1 →+0.582+0.089<.001.00137
BRCASERPINF1 →+0.579+0.040<.001.00237
GBMC1S →+0.442+0.070<.001<.00137
GBMMYO1F →+0.552+0.082<.001<.00137
GBMCRTAP →+0.587+0.096<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration