Response to stilbenoid

Across TCGA patient cohorts, RNA activity of the Response to stilbenoid pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VWA1, VWF, and CAVIN3_S62, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to stilbenoid activity versus VWA1 in CCRCC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VWA1 →	+0.574	+0.108	<.001	<.001	3	5
CCRCC	VWF →	+0.461	+0.091	.001	.001	3	5
BRCA	CAVIN3_S62 →	+0.546	+0.050	.001	.002	3	5
BRCA	CD34 →	+0.753	+0.067	<.001	<.001	3	5
OV	CD36 →	+1.342	+0.078	<.001	.001	2	6
OV	ADIPOQ →	+0.703	+0.067	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035634 vs VWA1 — CCRCC

Explore this scatter interactively →