Response to stilbenoid

Across TCGA cell cohorts, RNA activity of the Response to stilbenoid pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUK1, DNAJC18, and NCAPG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GUK1 grouped by Response to stilbenoid-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GUK1 →	-0.908	-1.536	<.001	<.001	3	5
LUNG_NSCLC_LUAD	DNAJC18 →	-0.927	-0.778	<.001	.003	3	4
LIVER	NCAPG2 →	-0.850	-1.673	.003	<.001	3	4
LIVER	ARSL →	+2.864	+1.472	.003	.005	3	4
LIVER	KCNK5 →	+2.361	+1.646	.003	<.001	3	4
LIVER	OVGP1 →	+1.408	+1.850	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GUK1 by Response to stilbenoid activity — LIVER

Explore this box plot interactively →