Response to stilbenoid

Across TCGA cell cohorts, RNA activity of the Response to stilbenoid pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMX2-CTNND1, MAPK8IP1, and SLC31A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMX2-CTNND1 grouped by Response to stilbenoid-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMX2-CTNND1 →	+0.203	+0.204	.006	.005	3	5
BLOOD_Leukemia	MAPK8IP1 →	+0.254	+0.140	<.001	<.001	3	4
LUNG_SCLC	SLC31A1 →	+0.212	+0.256	.004	.005	3	4
URINARY_TRACT	ALPI →	+0.200	+0.216	.006	.002	3	4
LUNG_SCLC	NYX →	+0.166	+0.273	.001	.004	3	4
LUNG_NSCLC_LUSC	NCDN →	+0.262	+0.274	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMX2-CTNND1 by Response to stilbenoid activity — LARGE_INTESTINE

Explore this box plot interactively →