Bone mineralization involved in bone maturation

Across TCGA patient cohorts, RNA activity of the Bone mineralization involved in bone maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCA4, COL6A2, and PALLD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone mineralization involved in bone maturation activity versus SMARCA4 in GBM (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMARCA4 →	-0.301	-0.067	<.001	<.001	3	7
BRCA	COL6A2 →	+0.738	+0.066	<.001	<.001	3	7
OV	PALLD →	+0.674	+0.059	<.001	<.001	3	7
GBM	PNN →	-0.418	-0.098	<.001	<.001	3	7
LSCC	BUD31 →	-0.217	-0.057	<.001	<.001	3	7
GBM	ASH2L →	-0.299	-0.072	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035630 vs SMARCA4 — GBM

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