Bone mineralization involved in bone maturation

Across TCGA cell cohorts, RNA activity of the Bone mineralization involved in bone maturation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCZ1B, SLC35E3, and ARAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCZ1B grouped by Bone mineralization involved in bone maturation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCZ1B →	+0.761	+1.398	.001	<.001	3	5
BREAST	SLC35E3 →	+0.929	+1.383	<.001	<.001	3	4
BLOOD_Leukemia	ARAP1 →	+0.827	+1.410	.003	.002	3	4
BLOOD_Leukemia	ITGB2 →	+2.942	+1.415	.002	.002	3	3
BREAST	PIGU →	+0.760	+1.053	.005	.002	3	3
LARGE_INTESTINE	EFTUD2 →	+0.626	+1.420	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCZ1B by Bone mineralization involved in bone maturation activity — BREAST

Explore this box plot interactively →