Bone mineralization involved in bone maturation

Across TCGA cell cohorts, RNA activity of the Bone mineralization involved in bone maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XPO4, GSTM2P1, and PDE6H, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XPO4 grouped by Bone mineralization involved in bone maturation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	XPO4 →	-0.148	-0.181	.006	.003	2	5
PANCREAS	GSTM2P1 →	+0.184	+0.183	.002	<.001	3	3
BREAST	PDE6H →	-0.096	-0.092	.002	.001	3	3
BREAST	B3GALNT1 →	-0.122	-0.104	<.001	<.001	3	3
BREAST	CHM →	+0.229	+0.134	.001	.006	3	3
BREAST	VDAC1 →	+0.278	+0.163	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XPO4 by Bone mineralization involved in bone maturation activity — OESOPHAGUS

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