Stress granule disassembly

Across TCGA patient cohorts, RNA activity of the Stress granule disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDFY4_S3123, SQOR, and RIDA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress granule disassembly activity versus WDFY4_S3123 in OV (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDFY4_S3123 →	-0.868	-0.040	.005	<.001	3	5
UCEC	SQOR →	-0.371	-0.047	<.001	.001	3	5
BRCA	RIDA →	+0.803	+0.052	<.001	.001	3	4
UCEC	SYNPO_S263 →	+0.669	+0.041	.007	.004	3	4
BRCA	YWHAZ →	+0.239	+0.043	<.001	<.001	3	4
CCRCC	CASP4 →	-0.381	-0.043	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035617 vs WDFY4_S3123 — OV

Explore this scatter interactively →