Stress granule disassembly

Across TCGA cell cohorts, RNA activity of the Stress granule disassembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C9orf72, TMCC2, and ABCF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress granule disassembly activity versus C9orf72 in KIDNEY (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C9orf72 →	+0.988	+0.195	<.001	<.001	3	5
PANCREAS	TMCC2 →	+0.744	+0.203	.005	.006	3	5
STOMACH	ABCF1 →	+1.092	+0.280	<.001	.002	3	5
BLOOD_Lymphoma	RPS6KC1 →	+1.019	+0.191	.003	.003	3	5
SKIN	NVL →	+0.517	+0.207	<.001	<.001	3	5
STOMACH	CHST14 →	+1.738	+0.247	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035617 vs C9orf72 — KIDNEY

Explore this scatter interactively →