Protein deglutamylation

pathway activity — cross-omics
GO:0035608Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Protein deglutamylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIMA1, LIMA1_S609, and PFN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCALIMA1 →-0.541-0.058<.001<.00135
BRCALIMA1_S609 →-0.607-0.056<.001.00235
GBMPFN2 →+0.490+0.081.001.00335
OVHSDL1 →+0.388+0.050<.001.00234
BRCASNRPC →+0.171+0.044.002.00234
BRCAUTP4 →+0.450+0.066<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration