Protein deglutamylation

pathway activity — cross-omics
GO:0035608Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Protein deglutamylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF3-AS1, ADAMTS4, and FOLH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECARHGEF3-AS1 →-0.771-0.786.002.00334
LUADADAMTS4 →+0.859+0.165.002.00333
LSCCFOLH1 →+1.110+0.777.001<.00133
GBMANKRD61 →-0.462-0.747<.001<.00133
GBMS1PR5 →+0.744+0.571<.001<.00133
GBMZKSCAN7 →-0.323-0.579.003.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration