Purinergic nucleotide receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Purinergic nucleotide receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAPC1, GNAI2, and PLEC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purinergic nucleotide receptor signaling pathway activity versus SNAPC1 in CNS (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SNAPC1 →	+1.966	+0.191	.006	.001	3	5
BREAST	GNAI2 →	+1.213	+0.843	<.001	.002	3	5
SKIN	PLEC →	+1.306	+0.341	<.001	.002	3	4
LUNG_SCLC	GPR161 →	+2.894	+2.307	.003	.003	2	5
STOMACH	IRS1 →	+1.759	+0.998	<.001	.007	3	4
BLOOD_Leukemia	SFXN3 →	+2.312	+0.563	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035590 vs SNAPC1 — CNS

Explore this scatter interactively →