Purinergic nucleotide receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Purinergic nucleotide receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNAI2, CRTAP, and TMEM43, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purinergic nucleotide receptor signaling pathway activity versus GNAI2 in OESOPHAGUS (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GNAI2 →	+2.096	+1.249	<.001	.005	3	12
OESOPHAGUS	CRTAP →	+1.388	+0.853	.003	.005	3	6
BREAST	TMEM43 →	+1.304	+1.080	.001	.006	3	5
OESOPHAGUS	CCT5 →	-0.745	-0.852	.008	.003	3	5
KIDNEY	MRPS33 →	-0.751	-0.318	.001	<.001	3	5
BLOOD_Leukemia	P3H1 →	+1.242	+0.369	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035590 vs GNAI2 — OESOPHAGUS

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