G protein-coupled purinergic nucleotide receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled purinergic nucleotide receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENTPD7, RNU6-1226P, and TTL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled purinergic nucleotide receptor signaling pathway activity versus ENTPD7 in LUAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ENTPD7 →	-0.326	-0.172	.001	.007	3	4
CCRCC	RNU6-1226P →	-0.682	-0.610	.001	.001	3	4
LUAD	TTL →	-0.310	-0.200	<.001	<.001	3	3
GBM	MORF4L2 →	-0.247	-0.585	<.001	.004	3	3
GBM	USP9X →	-0.180	-0.591	.002	.004	3	3
BRCA	KIF26B →	-0.905	-0.314	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035589 vs ENTPD7 — LUAD

Explore this scatter interactively →