G protein-coupled purinergic nucleotide receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled purinergic nucleotide receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TEAD1_S20, P2RY8_S324, and RNASEH2C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled purinergic nucleotide receptor signaling pathway activity versus TEAD1_S20 in UCEC (Pearson r = -0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEAD1_S20 →	-1.350	-0.638	<.001	<.001	3	3
PDAC	P2RY8_S324 →	+0.850	+0.273	<.001	<.001	3	3
COAD	RNASEH2C →	-0.303	-0.305	.001	<.001	3	3
BRCA	PRKD3_S213 →	+0.773	+0.679	<.001	<.001	3	3
UCEC	RGS19_S72 →	+0.948	+0.551	<.001	<.001	2	3
LSCC	RNF146_S293 →	-1.053	-0.461	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035589 vs TEAD1_S20 — UCEC

Explore this scatter interactively →