G protein-coupled purinergic nucleotide receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled purinergic nucleotide receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCTN3, SHPRH, and KDM4D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCTN3 grouped by G protein-coupled purinergic nucleotide receptor signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TCTN3 →	-0.754	-0.780	.001	.007	3	4
LUNG_SCLC	SHPRH →	+0.922	+1.072	.006	.008	3	4
STOMACH	KDM4D →	+0.534	+1.029	.007	.009	3	4
BLOOD_Lymphoma	TNFRSF13C →	+4.017	+1.913	<.001	<.001	3	4
BLOOD_Lymphoma	SMARCB1 →	+1.665	+1.720	.004	<.001	3	4
SKIN	PLAGL2 →	+0.466	+1.053	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCTN3 by G protein-coupled purinergic nucleotide receptor signaling pathway activity — BREAST

Explore this box plot interactively →