G protein-coupled purinergic receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled purinergic receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MINK1, NONO, and MAZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled purinergic receptor signaling pathway activity versus MINK1 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MINK1 →	+0.330	+0.074	<.001	<.001	3	6
GBM	NONO →	-0.204	-0.067	<.001	<.001	3	6
GBM	MAZ →	-0.454	-0.076	<.001	.004	3	5
HNSC	RELCH →	+0.267	+0.128	.001	<.001	3	5
HNSC	SERPINB1 →	+0.621	+0.098	<.001	.002	3	5
GBM	SMC5 →	-0.225	-0.083	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035588 vs MINK1 — GBM

Explore this scatter interactively →