G protein-coupled purinergic receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled purinergic receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACP3, LDHD, and STX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled purinergic receptor signaling pathway activity versus ACP3 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACP3 →	+0.825	+0.363	<.001	.001	3	5
GBM	LDHD →	+0.430	+0.234	<.001	.001	3	4
UCEC	STX2 →	-0.694	-0.164	.001	.009	2	5
UCEC	SLC9A2 →	+1.136	+0.150	<.001	.009	3	4
HNSC	XKRX →	+0.853	+0.141	<.001	<.001	3	3
HNSC	RPSAP10 →	-0.038	-0.134	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035588 vs ACP3 — LSCC

Explore this scatter interactively →