Regulation of kidney size

Across TCGA patient cohorts, RNA activity of the Regulation of kidney size pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASXL1, NOL4L, and PLXNA3, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of kidney size activity versus ASXL1 in SCLC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ASXL1 →	+0.815	+0.373	<.001	<.001	3	19
ESCA	NOL4L →	+1.146	+0.079	<.001	<.001	3	17
SCLC	PLXNA3 →	+1.165	+0.427	<.001	.001	3	15
DLBC	NCOA6 →	+0.757	+0.130	<.001	<.001	3	15
DLBC	ATP11A →	+1.104	+0.120	<.001	<.001	3	15
DLBC	TRPC4AP →	+0.668	+0.157	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035564 vs ASXL1 — SCLC

Explore this scatter interactively →