Regulation of kidney size

Across TCGA patient cohorts, RNA activity of the Regulation of kidney size pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-DMB, SPATS2L_S338, and ZCCHC8_T479, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of kidney size activity versus HLA-DMB in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HLA-DMB →	+1.247	+0.218	<.001	<.001	3	5
LUAD	SPATS2L_S338 →	-0.561	-0.099	<.001	.001	3	4
LUAD	ZCCHC8_T479 →	+0.362	+0.111	.007	<.001	3	4
PDAC	GOLPH3L →	+0.299	+0.080	<.001	<.001	3	4
HNSC	EPB41_S684 →	+0.520	+0.131	<.001	.001	3	4
CCRCC	EVA1B →	-0.328	-0.097	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035564 vs HLA-DMB — HNSC

Explore this scatter interactively →