Regulation of kidney size

Across TCGA cell cohorts, RNA activity of the Regulation of kidney size pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNF1B, WNT7B, and SLFN14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HNF1B grouped by Regulation of kidney size-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HNF1B →	+2.083	+0.942	<.001	.001	3	4
OESOPHAGUS	WNT7B →	+1.533	+1.265	.002	.005	3	4
LIVER	SLFN14 →	-0.021	-2.135	.002	<.001	3	4
CNS	ARHGEF39 →	-0.779	-1.054	.003	.001	3	3
CNS	LY6K →	-1.704	-0.977	<.001	<.001	3	3
CNS	TONSL →	-0.675	-0.917	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HNF1B by Regulation of kidney size activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →