Regulation of kidney size

Across TCGA cell cohorts, RNA activity of the Regulation of kidney size pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNF1B, FOLR2, and RPS21, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HNF1B grouped by Regulation of kidney size-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HNF1B →	+0.328	+1.584	.003	<.001	3	6
STOMACH	FOLR2 →	-0.144	-1.416	<.001	<.001	3	5
OVARY	RPS21 →	+0.604	+2.497	.005	<.001	3	4
OVARY	CDC14A →	-0.278	-1.836	<.001	<.001	3	4
CNS	COL1A2 →	+0.165	+0.128	.007	.008	3	4
SOFT_TISSUE	TCF7 →	-0.167	-1.819	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HNF1B by Regulation of kidney size activity — PANCREAS

Explore this box plot interactively →