Proline transmembrane transport

Across TCGA patient cohorts, RNA activity of the Proline transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPN2, PDLIM4, and SLC7A8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline transmembrane transport activity versus EPN2 in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EPN2 →	+0.318	+0.088	.001	<.001	3	5
PDAC	PDLIM4 →	+0.319	+0.041	<.001	.005	3	5
LSCC	SLC7A8 →	+0.783	+0.064	.001	.002	3	4
GBM	COL5A1 →	+0.711	+0.075	<.001	.002	3	4
GBM	CTHRC1 →	+0.640	+0.071	.002	.006	3	4
LUAD	FLNA_S968 →	+1.013	+0.082	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035524 vs EPN2 — UCEC

Explore this scatter interactively →