Proline transmembrane transport

Across TCGA patient cohorts, RNA activity of the Proline transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF2, ZNF684, and TNFRSF11A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline transmembrane transport activity versus ARHGEF2 in PDAC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ARHGEF2 →	-0.218	-0.351	.009	.004	3	4
HNSC	ZNF684 →	-0.464	-0.757	.002	<.001	3	3
HNSC	TNFRSF11A →	-0.627	-0.803	.001	.001	3	3
HNSC	MCOLN2 →	-0.848	-0.849	.005	.001	3	3
HNSC	TMCO4 →	-0.456	-0.587	.002	.006	3	3
HNSC	ASMTL →	-0.369	-0.750	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035524 vs ARHGEF2 — PDAC

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