Proline transmembrane transport

Across TCGA cell cohorts, RNA activity of the Proline transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COTL1, CLDN11, and PWP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COTL1 grouped by Proline transmembrane transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COTL1 →	-1.747	-0.759	.007	.002	3	4
LUNG_NSCLC_LUSC	CLDN11 →	-4.525	-1.548	.001	<.001	3	4
OVARY	PWP1 →	-0.844	-1.074	<.001	<.001	3	4
OVARY	SMIM1 →	+1.640	+0.934	.001	.004	3	4
BONE	LRRFIP2 →	-1.311	-1.760	.008	.002	3	4
CNS	PMP22 →	-1.876	-1.180	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COTL1 by Proline transmembrane transport activity — BREAST

Explore this box plot interactively →