Protein K29-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K29-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVK, ARFGEF3, and CIT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K29-linked deubiquitination activity versus MVK in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MVK →	+0.285	+0.603	.003	<.001	3	3
LUAD	ARFGEF3 →	+0.535	+0.553	.003	.001	3	3
LUAD	CIT →	+0.764	+0.703	.004	<.001	3	3
LUAD	APOL2 →	-0.279	-0.467	.007	.008	3	3
LUAD	REPS1 →	+0.241	+0.617	.003	.005	3	3
LUAD	HSF2 →	+0.284	+0.721	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035523 vs MVK — LUAD

Explore this scatter interactively →