Protein K29-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K29-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCC, NCAPG2, and GSR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCC grouped by Protein K29-linked deubiquitination-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FANCC →	-1.037	-1.247	.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	NCAPG2 →	-1.467	-1.247	.001	.003	3	3
OESOPHAGUS	GSR →	-2.306	-0.613	.005	<.001	3	3
CNS	POLR3F →	+0.993	+2.229	<.001	<.001	3	3
BREAST	ZNF695 →	-0.884	-0.816	.003	<.001	3	3
BONE	CUL9 →	-1.772	-0.575	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCC by Protein K29-linked deubiquitination activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →