Monoubiquitinated protein deubiquitination

Across TCGA patient cohorts, RNA activity of the Monoubiquitinated protein deubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATXN3, ZFYVE1, and HDLBP_S944, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoubiquitinated protein deubiquitination activity versus ATXN3 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATXN3 →	+0.351	+0.065	<.001	<.001	3	9
BRCA	ZFYVE1 →	+0.251	+0.045	<.001	<.001	3	7
CCRCC	HDLBP_S944 →	-0.703	-0.055	<.001	<.001	3	7
COAD	PACS2 →	+0.388	+0.058	<.001	.001	3	7
CCRCC	RPL7 →	-0.223	-0.057	<.001	<.001	3	6
CCRCC	RPS2 →	-0.263	-0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035520 vs ATXN3 — HNSC

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