Monoubiquitinated protein deubiquitination

Across TCGA patient cohorts, RNA activity of the Monoubiquitinated protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COMMD3, WAC-AS1, and BUB1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoubiquitinated protein deubiquitination activity versus COMMD3 in GBM (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COMMD3 →	-0.540	-0.651	<.001	<.001	3	4
GBM	WAC-AS1 →	-0.461	-0.543	<.001	.008	3	4
UCEC	BUB1B →	+0.834	+0.388	.002	<.001	3	4
OV	ZWINT →	+0.728	+0.407	.005	.005	3	3
LUAD	PPFIA2 →	-0.485	-0.314	.003	.006	3	3
OV	C1QTNF7 →	-0.604	-0.317	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035520 vs COMMD3 — GBM

Explore this scatter interactively →