Monoubiquitinated protein deubiquitination

Across TCGA cell cohorts, RNA activity of the Monoubiquitinated protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KARS1, RSL1D1, and TCF25, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoubiquitinated protein deubiquitination activity versus KARS1 in LUNG_NSCLC_LUAD (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KARS1 →	+0.717	+1.159	<.001	<.001	3	7
CNS	RSL1D1 →	+0.789	+1.006	<.001	<.001	3	5
OVARY	TCF25 →	+0.802	+0.998	.006	.002	3	5
KIDNEY	ZCCHC14 →	+1.104	+1.367	.003	<.001	2	5
BONE	AXIN1 →	+0.896	+0.978	.004	.003	3	4
BONE	NAGK →	-1.131	-1.183	.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035520 vs KARS1 — LUNG_NSCLC_LUAD

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