Protein K29-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K29-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH7B, ANK3, and CCDC191, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYH7B grouped by Protein K29-linked ubiquitination-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MYH7B →	+0.539	+0.244	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ANK3 →	+2.918	+0.328	.002	.002	3	4
OESOPHAGUS	CCDC191 →	+0.832	+0.231	.005	.005	3	4
OVARY	NMT2 →	-1.090	-0.801	.005	.008	3	3
CNS	NKIRAS2 →	-0.431	-0.754	.006	.007	3	3
CNS	EEF1G →	+0.374	+0.759	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYH7B by Protein K29-linked ubiquitination activity — OESOPHAGUS

Explore this box plot interactively →