Protein K29-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K29-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU2F1, RPRD1A, and CENPV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K29-linked ubiquitination activity versus POU2F1 in LUNG_SCLC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	POU2F1 →	+0.681	+0.961	<.001	<.001	3	6
KIDNEY	RPRD1A →	+0.999	+0.595	.001	.001	3	5
BREAST	CENPV →	+2.336	+0.699	.005	.009	3	5
BLOOD_Leukemia	ACVR2B →	+0.807	+0.862	<.001	<.001	3	5
LUNG_SCLC	CD63 →	-1.094	-1.096	.001	.006	3	5
BLOOD_Leukemia	EAF1 →	+0.539	+0.824	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035519 vs POU2F1 — LUNG_SCLC

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