Oxidative RNA demethylation

Across TCGA patient cohorts, RNA activity of the Oxidative RNA demethylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FTO, STT3B_S498, and RPL11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative RNA demethylation activity versus FTO in LSCC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FTO →	+0.370	+0.062	<.001	<.001	3	7
LUAD	STT3B_S498 →	-0.339	-0.031	.005	.003	3	5
BRCA	RPL11 →	-0.210	-0.028	<.001	.006	3	5
BRCA	NFATC4_S311 →	+0.683	+0.036	.003	.003	3	5
GBM	L3HYPDH →	+0.469	+0.043	.004	.001	3	5
GBM	PAXBP1 →	-0.199	-0.041	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035513 vs FTO — LSCC

Explore this scatter interactively →