Metanephric part of ureteric bud development

Across TCGA patient cohorts, RNA activity of the Metanephric part of ureteric bud development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRPPRC, MRPS10, and LTBP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric part of ureteric bud development activity versus LRPPRC in OV (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRPPRC →	-0.288	-0.074	<.001	<.001	3	6
COAD	MRPS10 →	-0.281	-0.090	.006	<.001	3	6
LUAD	LTBP2 →	+0.608	+0.114	<.001	.007	3	5
BRCA	CS →	-0.247	-0.110	<.001	<.001	3	5
BRCA	MRPS31 →	-0.305	-0.088	<.001	.002	3	5
BRCA	PNPT1 →	-0.328	-0.075	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035502 vs LRPPRC — OV

Explore this scatter interactively →