Metanephric part of ureteric bud development

Across TCGA cell cohorts, RNA activity of the Metanephric part of ureteric bud development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHX1, WT1, and FOXJ1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LHX1 grouped by Metanephric part of ureteric bud development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LHX1 →	-0.345	-1.124	.008	.007	3	12
CNS	WT1 →	-0.227	-1.548	<.001	<.001	3	11
BLOOD_Myeloma	FOXJ1 →	-0.334	-0.933	<.001	.004	3	11
STOMACH	CALB1 →	-0.178	-0.882	<.001	.003	3	7
LUNG_SCLC	ZNF451 →	+0.225	+1.195	.002	.004	2	6
LIVER	CRIM1 →	+0.401	+1.392	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LHX1 by Metanephric part of ureteric bud development activity — BLOOD_Leukemia

Explore this box plot interactively →