Metanephric part of ureteric bud development

Across TCGA cell cohorts, RNA activity of the Metanephric part of ureteric bud development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF16, KIAA1958, and DDB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCAF16 grouped by Metanephric part of ureteric bud development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DCAF16 →	-0.816	-1.607	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	KIAA1958 →	-1.012	-1.634	.002	.007	3	5
OVARY	DDB2 →	+1.335	+1.174	<.001	.001	3	4
BREAST	KLHL15 →	-0.704	-1.086	.003	.001	3	4
PANCREAS	SLC25A39 →	-1.153	-1.270	.002	.009	3	4
PANCREAS	CCDC43 →	-0.691	-1.265	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCAF16 by Metanephric part of ureteric bud development activity — KIDNEY

Explore this box plot interactively →