Gastric motility

pathway activity — cross-omics
GO:0035482Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Gastric motility pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, TYMP, and EBI3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTNFAIP3 →+0.748+0.204.001.00136
HNSCTYMP →+1.232+0.358<.001.00427
OVEBI3 →+1.050+0.821<.001.00635
OVSECTM1 →+2.078+0.942<.001.00335
OVCTLA4 →+0.935+0.851.003.00435
OVICOS →+0.759+0.717.002.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration