Positive regulation of vascular wound healing

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular wound healing pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFB, FOXC2, and XBP1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular wound healing activity versus VEGFB in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VEGFB →	+1.536	+0.297	<.001	<.001	3	17
URINARY_TRACT	FOXC2 →	-1.901	-0.189	.001	.006	3	11
BONE	XBP1 →	+1.873	+0.275	<.001	<.001	3	10
BREAST	FKBP2 →	+0.808	+0.217	<.001	<.001	2	10
UPPER_AERODIGESTIVE_TRACT	SMOC2 →	-1.478	-0.192	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	TRPT1 →	+0.829	+0.174	.002	.005	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035470 vs VEGFB — STOMACH

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