Determination of pancreatic left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of pancreatic left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPCD, WDR35, and IFT140, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of pancreatic left/right asymmetry activity versus DPCD in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DPCD →	+0.552	+0.651	<.001	<.001	3	8
UCEC	WDR35 →	+0.520	+0.164	<.001	<.001	3	7
BRCA	IFT140 →	+0.625	+0.136	<.001	<.001	3	7
GBM	IFT74 →	+0.535	+0.646	<.001	<.001	3	7
UCEC	OSCP1 →	+0.836	+0.179	<.001	<.001	3	7
UCEC	SPA17 →	+0.758	+0.201	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035469 vs DPCD — GBM

Explore this scatter interactively →